Composition
Each 5 ml of syrup contains:
cefixime (as Trihydrate) 50 mg after reconstituted with water.

Product Description
RESPICLAV DRY SYRUP (CEFIXIME) is a semisynthetic, third generation cephalosporin antibiotic for oral administration.

Mechanism of Action
Bactericidal action of RESPICLAV DRY SYRUP results from inhibition of cell-wall synthesis. RESPICLAV DRY SYRUP is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.

Pharmaco Kinetics
RESPICLAV DRY SYRUP, given orally, is about 40% to 50% absorbed whether administered with or without food. Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours. The drug is not cleared significantly from the blood by hemodialysis or peritoneal dialysis. However, a study indicated that with doses of 400 mg, patients undergoing hemodialysis have similar blood profiles as subjects with creatinine clearances of 21-60 mL/min. There is no evidence of metabolism of cefixime in vivo .

Indications
RESPICLAV DRY SYRUP (cefixime (as Trihydrate)) is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms:
• Uncomplicated Urinary Tract Infections
• Otitis Media
• Pharyngitis And Tonsillitis
• Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis
• Uncomplicated Gonorrhea (cervical/urethral)

Contra Indications
RESPICLAV DRY SYRUP is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects:
The following adverse reactions have been reported following the use of RESPICLAV DRY SYRUP. Incidence rates were less than 1 in 50 (less than 2%). Diarrhea, loose stools, abdominal pain, dyspepsia, nausea, and vomiting

Drug Interactions
Carbamazepine: Elevated carbamazepine levels have been reported DRUG/LABORATORY TEST INTERACTIONS:

PEDIATRIC USE:
Safety and effectiveness of RESPICLAV DRY SYRUP in children aged less than 6 months old have not been established.

Dosage
Children: The recommended dose is 8 mg/kg/day of the suspension. This may be administered as a single daily dose or may be given in two divided doses, as 4 mg/kg every 12 hours.

Packing
Respiclav Dry Syrup Powder for Oral Suspension 11gm / 30ml