Composition
Each tablet contains
Telmisartan 40Mg and Amlodipine 5Mg

Product Description
Telmisartan
Telmisartan is an oral Anti Hypertensive drug of the class Angiotensin Receptor Blocker with a half life of more than 24 hrs
Structural formula
2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid
Molecular formula
C33H30N4O2
Molecular weight
514.617 g/mol

Amlodipine
Amlodipine is an oral Anti Hypertensive drug of the class Calcium channel blocker
Structural formula
RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular formula
C20H25ClN2O5
Molecular weight
408.879 g/mol

Mechanism of action
Telmisartan is a member of a family of drugs called angiotensin receptor blockers (ARBs),. ARBs block the ability of the chemical angiotensin II to constrict or squeeze arteries and veins by blocking the Angiotensin 2 binding to the AT1 receptor. As a result, the arteries and veins enlarge and blood pressure falls. The reduced pressure in the arteries also makes it easier for the heart to pump blood. Telmisartan was approved by the FDA in November of 2000.

Amlodipine belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, amlodipine is useful in preventing chest pain angina resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscle's demand for oxygen, and further helps to prevent angina in patients with coronary artery disease.

Indications
In Hypertension with coronary artery disease
In hypertension with obesity
In hypertension with diabetes
In hypertension with dyslipidemia and in elderly

Adverse Effects
Telmisartan is well tolerated Headache, upper respiratory tract infection, dizziness, pain, back pain, fatigue, diarrhoea, sinusitis, influenza like symptoms, dyspepsia, myalgia, coughing, chest pain, urinary tract infection, nausea, pharyngitis, and abdominal pain have been reported.

ContraIndication
Hypersensitivity to any ingredient; pregnancy and lactation; biliary obstructive disorders; severe hepatic impairment; severe renal impairment, cardiogenic shock unstable angina, aortic stenosis.

Special Precautions
Renovascular hypertension; renal impairment and kidney transplant; intravascular volume depletion; other conditions with stimulation of the renin-angiotensin-aldosterone system; primary aldosteronism; aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy; hyperkalaemia; hepatic impairment; active gastric or duodenal ulcer or gastrointestinal pathologies, sorbitol; others.

Drug Interactions
other antihypertensives, digoxin and lithium.

Dosage
Once Daily.

Packing
A strip of 10 tablets.
In a box 10x10 tablets