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    PTF >>Anti inflammatory agent>>Steplor P


Composition
Each film coated tablet contains:
Lornoxicam 8 mg & Paracetamol IP 500 mg

Lornoxicam
Lornoxicam (chlortenoxicam), a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties, is available in oral and parenteral formulations.

Paracetamol
Paracetamol is a widely used TIME TESTED & TIME TRUSTED , over-the-counter analgesic (pain reliever) and antipyretic. It is commonly used for the relief of headaches, and other minor aches and pains,
In combination with opioid analgesics, Paracetamol could be used also in the management of more severe pain (such as in advanced cancer)

Pharmacology
Lornoxicam inhibits prostaglandin biosynthesis by blocking the enzyme Cyclo oxygenase.

Lornoxicam inhibits both isoforms in the same concentration range, that is, Balanced COX-1 Inhibition & COX-2 inhibition through that it’s a safest pain killer.

Paracetamol is usually classified along with nonsteroidal anti-inflammatory drugs (NSAID), Like all drugs of this class, its main mechanism of action is the inhibition of Cyclo oxygenase (COX),

Contra Indications
Patients with peptic ulceration; severe renal impairment; pregnancy and lactation.


Drug Interaction
Increased lornoxicam blood conc when given concomitantly with cimetidine.Enhanced effects of anticoagulants, sulfonylureas, methotrexate, ciclosporin, digoxin. Decreased effects of diuretics, ACE inhibitors.

Features
* Rapid onset of action.
* Excellent G.I Tolerability & Long term safety.
* Safest pain killer for High Risk groups patients like Hypertensive’s, Cardiac Patients , Diabetics & Renal failure patients.

Indications
* Musculo skeletal pain
* Low back pain
* Post operative pain
* Arthritis [Osteo & Rhumatoid Arthritis

Dosage
1 - 2 tablets per day

Storage
Stored in dry place not exceeding 25 degree celcious, Protected From Light.
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